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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Ring Finger Protein 213 (RNF213)

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Ring finger protein 213 (RNF213) has recently emerged as a versatile immune sensor. It restricts the growth of:

Gram-negative bacteria

Gram-positive bacteria

Parasites / Parasitism

Viruses

Otten et al. 2021 Nature 594: 111-116
Thery et al. 2021 Nat. Commun. 12: 5772
Hernandez et al. 2022 mBio 13: e0188822
Walsh et al. 2022 Cell Host & Microbe 30(12): 1671-1684

Ring Finger Protein 213 (RNF213) is a large and unusual E3 ligase that mediates the direct and non-canonical ester-linked [ubiquitylation](brain://5gK5me1wEkitztL8K6K0iQ/Ubiquitylati…

References (Sources)

Interferon-Inducible E3 Ligase RNF213 Facilitates Host-Protective Linear and K63-Linked Ubiquitylation of Toxoplasma gondii Parasitophorous Vacuoles
Hernandez et al. 2022 mBio 13: e0188822
Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism
Ahel et al. 2020 eLife 9: e56185
Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity
Thery et al. 2021 Nat. Commun. 12: 5772
The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction
Walsh et al. 2022 Cell Host & Microbe 30(12): 1671-1684
Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection
Otten et al. 2021 Nature 594: 111-116

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2/26/2026

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Ring Finger Protein 213 (RNF213)

Welcome to meRfi-GM!

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