G-protein coupled receptors (GPCRs)

For many years, it was believed that G-protein coupled receptors (GPCRs) signaled solely at the plasma membrane. However, research conducted over the past 15 years has uncovered that these receptors also engage in signaling through classical G-protein-mediated pathways on the membranes of intracellular organelles, including endosomes and the Golgi complex.
Calebiro et al. 2025 Trends in Biochemical Sciences 50(1): 46

The Thyrotropin receptor, Parathyroid hormone receptor (PTHR) and Beta-2 adrenergic receptor are three examples
Calebiro et al. …