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G-protein coupled receptors (GPCRs)
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For many years, it was believed that G-protein coupled receptors (GPCRs) signaled solely at the plasma membrane. However, research conducted over the past 15 years has uncovered that these receptors also engage in signaling through classical G-protein-mediated pathways on the membranes of intracellular organelles, including endosomes and the Golgi complex.
The Thyrotropin receptor, Parathyroid hormone receptor (PTHR) and Beta-2 adrenergic receptor are three examples
Calebiro et al. …
References (Sources)
- Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor
- GPCR Dynamics: Structures in Motion
- Historical review: a brief history and personal retrospective of seven-transmembrane receptors
- Mutschler Arzneimittelwirkungen
- The N terminus-only function of adhesion GPCRs: emerging concepts
- The role of receptor kinases and arrestins in G protein-coupled receptor regulation
- What is holding back preclinical GPR119 agonists from their potential as the therapeutics of type 2 diabetes?