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Myeloid cells, particularly macrophages, are the main cell type involved in inflammasome assembly
Myeloid cells (macrophages, monocytes, dendritic cells, and granulocytes) survey the body for infections and damage and regulate tissue homeostasis, organogenesis, and immunity.
Myeloid cells are components of the innate immune system that represent the first line of defense.
Inflammatory responses triggered by myeloid cells after sensing tissue injury can contribute to resolution of the damage.
The signaling response following dead-cell sensing by myeloid cells can contribute either to an inflammatory or a regulatory response.
see also:
Damaged Tissue