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cyclic GMP-AMP (cGAMP)
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This is a hybrid molecule that exists in different forms, such as 2'3'-cGAMP and 3'3'-cGAMP. In mammals, cGAMP is synthesized by the enzyme Cyclic GMP-AMP synthase (cGAS) in response to cytosolic DNA and plays a pivotal role in activating the cGAS-STING Pathway (Stimulator of Interferon Genes) pathway, leading to immune responses.
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