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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Bile acids / Bile salts biosynthesis & Hepatocytes

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Primary Bile Acids / Primary Bile Salts (PBAs) are synthesized in hepatocytes by two pathways: the classic pathway initiated by Cholesterol 7 alpha-hydroxylase (CYP7A1) and the alternative, neutral pathway initiated by 24-hydroxycholesterol-7 alfa hydroxylase (CYP27A1/CYP7B1)
Fuchs & Trauner 2022 Nat Rev Gastroenterol Hepatol 19: 432-450
Taylor et al. 2022 Drug Metab Dispos 50: 456-467

Primary BS synthesized by CY7A1 and CYP27A1

Developmental Patterns of Fecal Bile Acids in Healthy Neonates and Children
Xiong et al. 2021
Environmental Chemical Contribution to the Modulation of Bile Acid Homeostasis and Farnesoid X Receptor Signaling
Taylor et al. 2022 Drug Metab Dispos 50: 456-467
Review
Interactions between bile salts, gut microbiota, and hepatic innate immunity
Schubert et al. 2017 Immunological Reviews 279: 23-35
Review
Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology
Fuchs & Trauner 2022 Nat Rev Gastroenterol Hepatol 19: 432-450
Review
The Liver under the Spotlight: Bile Acids and Oxysterols as Pivotal Actors Controlling Metabolism
Lefort & Cani 2021
Review

12/15/2025