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The inside of a grown-up human's intestines is lined with one layer of tall, thin cells. These cells come from special cells called intestinal stem cells (ISCs). In a lab model called the intestine-on-a-chip (IOAC), scientists take ISCs and gut bacteria from a person and grow them together in a special chip with many channels. This chip is designed to act like a real intestine, copying things like the flow of fluids, movements similar to digestion, communication between the body and bacteria, and interactions between different types of cells.
Li et al. 2022 Stem Cell Reviews and Reports 18: 213…