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Cell death in gut cells dependent on caspase-3 and caspase-7 activity affects Salmonella growth in mice. Staurosporine or doxorubicin causes cell death and increases Salmonella growth, even though doxorubicin usually kills bacteria. This shows that specific cell death processes in the gut are important for Salmonella to thrive.
In a conventional mouse model, Salmonella must directly compete with commensal microbiota for a nutritional niche
Sommer et al. 2017 Na…