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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Acetyl-CoA

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Acetyl-CoA, the starting material for acetate, butyrate, and propionate, is reached from pyruvate.
Deleu et al. 2021 EBioMedicine 66: 103293

Pyruvate can be subsequently converted into acetyl-CoA in the mitochondria to fuel the tricarboxylic acid cycle (TCA) cycle
Tan et al. 2021b Nutrients 13: 823

Gradual consumption of Fructose promotes hepatic lipogenesis from ACLY- and ACSS2-derived…

Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate
Zhao et al. 2020e Nature 579: 586-591
Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer
Davidson et al. 2016 Cell Metab. 23: 517–528
GS-0976 (Firsocostat): an investigational liverdirected acetyl-CoA carboxylase (ACC) inhibitor for the treatment of non-alcoholic steatohepatitis (NASH)
Alkhouri et al. 2020 Expert Opin. Investig. Drugs 29(2): 135-141
Review
How Changes in the Nutritional Landscape Shape Gut Immunometabolism
Tan et al. 2021b Nutrients 13: 823
Review
Short chain fatty acids and its producing organisms: An overlooked therapy for IBD?
Deleu et al. 2021 EBioMedicine 66: 103293
Review

5/29/2026