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Irinotecan treatment has been associated with an increase in bacteria that produce beta-glucuronidase, contributing to mucositis-related diarrhea.
Irinotecan treatment alters the flora of rats' stomachs, jejunum, colon, and feces and is associated with diarrhea. These changes in flora may contribute to the development of chemotherapy-induced mucositis.
see also:
Adverse Events / Safety & Irinotecan
[Diarrhea …