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Harmonious cell-cell communication involving microglia is crucial for maintaining the healthy state of the tissue environment and overcoming pathologies such as neuroinflammation. Analyses of these intercellular pathways have enhanced our understanding of the heterogeneous but context-associated microglial responses to environmental cues across various neuropathologies. These include:
Microglia, the resident myeloid cells in the central nervous system, are critically involved in the pathogenesis of Alzheimer's Disease (AD) and have emerged as a potential therapeutic target for treating or preventing Alzheimer's disease (AD). The failure of microglia to keep up with persistent Amyloid-beta (Aß, Abeta) / Amyloid Plaques development, along with the secretion of pro-inflammatory cytokines, is detrimental to neurons and favors Amyloid-beta (Aß, Abeta) / Amyloid Plaques accumulation.
Microglia are emerging as important regulators of neuronal function and behavior in almost all areas of neuroscience. Initially, the focus was on microglia's classical immune functions in pathological contexts. Terms such as “microglia activation” or “neuroinflammation” are used ubiquitously to describe changes in neuroimmune function in different contexts.
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see also:
Alzheimer's Disease (AD) & Microglia
Alzheimer's Disease (AD) & Pathogenicity
Immunity & Microglia
Microglia