CD284 (Toll-Like Receptor 4 (TLR-4))

It cooperates with LY96 (also referred as MD-2) and CD14 to mediate in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria.

CD284 (Toll-Like Receptor 4 (TLR-4)) is localized on cell membranes of CD11c + Conventional dendritic cell (cDC) / myeloid dendritic cell (mDC)), Monocytes, Basophils, Mastocytes / Mast cells
Shekarian et al. 2017 Ann Oncol. 28(8): 1756-1766

TLR-4 activation by bacterial LPS in the gut exacerbates intestinal mucosal damage and Bacterial Translocation / Intestinal permeability
Carotti et al. 2015 World J. Gastrointest. Pathophysiol. 6: 99–109

Toll-Like Receptor 3 (TLR-3) engagement increases production of Interferons Type I (IFN Type I) and Interferon type III (IFN Type III). TLR4 induces IFNs using CD14. This causes relocalization. It moves from the plasma membrane and goes into the endosomal compartment. This happens when it senses lipopolysaccharide (LPS) from gram-negative bacteria.
Zanoni et al. 2011 Cell 147: 868-880

TLR-4 has been identified as one of the regulators of the mucosal immune system to Lipopolysaccharides (LPS)
Fukata et al. 2009

CD284 (Toll-Like Receptor 4 (TLR-4)) uses both Myeloid Differentiation Primary Response 88 (MYD88) and TIR domain containing adaptor molecule 1 (TICAM1)
West et al. 2006 Annu Rev Cell Dev Biol. 22: 409-37

see also:
CD284 (Toll-Like Receptor 4 (TLR-4)) agonists
CD284 (Toll-Like Receptor 4 (TLR-4)) / MYD88 / NFKB signaling pathway
PAMPs (pathogen-associated molecular patterns) & Toll-Like Receptors (TLRs)