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Plasmacytoid Dendritic Cells (pDC) originate from a common DC progenitor (CDP) or a CD115- a subset of a common DC progenitor (CDP)
Plasmacytoid Dendritic Cells (pDCs) express markers CD11c-, CD123, CD303 (BDCA-2) and CD304 unlike other dendritic cell types and are typically identified in blood
Plasmacytoid Dendritic Cells (pDCs) specialize in releasing Interferon alfa (IFN-alfa) and Interferon beta (IFN-beta) upon recognition of viral or endogenous nucleic acids via Toll-like receptor 7 (TLR-7) and Toll-like receptor 9 (TLR-9)
Plasmacytoid DCs (PDCs) exposed to PSA do not produce Pro-inflammatory Cytokines, but instead, they specifically stimulate IL-10 secretion by CD4+ T cells
Dasgupta et al. 2014 Cell Host and Microbe. 15: 413-423
PSA induces and preferentially ligates Toll-like receptor 2 (TLR-2) on Plasmacytoid Dendritic Cells (pDCs) but not on Conventional (or classical) dendritic cells (cDCs)
Dasgupta et al. 2014 Cell Host and Microbe. 15: 413-423
Compared with other TLR-2 ligands, PSA enhances the PDC expression of co-stimulatory molecules required for protection against colitis.
Dasgupta et al. 2014 Cell Host and Microbe. 15: 413-423
Plasmacytoid Dendritic Cells (pDCs) can thus orchestrate the beneficial immunoregulatory interaction of commensal microbial molecules, such as PSA, through both innate and adaptive immune mechanisms.
Dasgupta et al. 2014 Cell Host and Microbe. 15: 413-423
see also:
Plasmacytoid Dendritic Cells (PDCs) & Toll-like receptors (TLRs)