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Marker: CD11c (Integrin Alfa X (ITGAX)) HLADR+ CD40+ CD86+
Conventional (or classical) Dendritic Cells (cDCs) have various pathogen recognition receptors (PRRs) on their surface, such as TLRs, C-type lectin receptors (CLRs), mitochondrial antiviral signaling (MAVS) protein, stimulator of interferon genes (STING), NLRs, IL-1R family receptors, and TNF receptor superfamily (TNFRSF)
Conventional dendritic cells (cDCs) can integrate multiple stimuli from the environment and provide three separate outputs in terms of antigen presentation, costimulation, and cytokine production
Conventional (or classical) dendritic cells (cDCs) are further subdivided into Conventional (or classical) Dendritic Cell 1 (cDC1) and Conventional (or classical) Dendritic Cells 2 (cDC2) that specialize in presenting antigens to naive CD8 + and CD4 + T cells, respectively.
The progeny of Common Dendritic Cell Precursor (CDP), including committed precursors for Conventional (or classical) Dendritic Cell 1 (cDC1) (pre-cDC1) and Conventional (or classical) Dendritic Cells 2 (cDC2) (pre-cDC2), arise in the Bone marrow (BM) and complete their terminal differentiation in the peripheral tissues.
They share with monocytes a Bone marrow (BM) precursor called monocyte-DC progenitor (MDP), which gives rise to a Common Dendritic Cell Precursor (CDP)
Mature and immature Conventional (or classical) dendritic cells (cDCs) have different cytokine expression patterns.
TLR-1/2, TLR-2/6, TLR-3, TLR-4, TLR-5, TLR-8
Shekarian et al. 2017 Ann Oncol. 28(8): 1756-1766
Mature myeloid dendritic cells (DCs) secrete IL-1, IL-6, IL-7, IL-12, IL-15, and IL-18
see also:
Immature DC (iDC) / Langerhans Cells