Conventional (or classical) Dendritic Cell 1 (cDC1)

typically identified in blood

A specific subset of Conventional (or classical) Dendritic Cells (cDCs) specialized in cross-presentation express XCR1, C-type lectin domain family 9 member A (CLEC9A) and CD141 / Thrombomodulin and are referred to as Conventional (or classical) Dendritic Cell 1 (cDC1) (2).

they are able to promote the differentiation and maturation of CD8+ T cells, and cDC1 cells can recruit CCL5 and XCL1, which induce the accumulation of cDC1 cells in the TME, thereby improving the immune control of tumors (1)

In humans, CD40 ligand (CD40L)-activated monocyte-derived DCs (DC1), but not Conventional (or classical) Dendritic Cells 2 (cDC2), produce a large amount of Interleukin-12 (IL-12) and induce CD4+ Th1 cell responses versus CD4+ Th2 Cell Responses (3).

However, several studies have shown that a specific DC subset can trigger either a Th1 or Th2 response, depending on the types of stimulation and pathogens (4, 5, 6).

References:

(1) Qiu et al. 2021a Front. Immunol.11: 612202
(2) Hildner et al. 2008 Science 322: 1097-1100
(3) Rissoan et al. 1999 Science 283: 1183-1186
(4) d’Ostiani et al. 2000 J Exp Med 191: 1661-1674
(5) Whelan et al. 2000 J Immunol 164: 6453-6460
(6) Kadowaki et al. 2000 J Exp Med 192: 219-226