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Toll-like receptor 9 (TLR-9)
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Contents
Toll-like receptor 9 (TLR-9) is a transmembrane protein that recognizes unmethylated CpG DNA motifs in endosomes and activates inflammatory and antiviral responses via the MyD88 adaptor protein
Toll-like receptor 9 (TLR-9) engagement increases production of Interferons Type I (IFN Type I), Chemokine (C-X-C motif) ligand 9 (CXCL9), and Chemokine (C-X-C motif) ligand 10 (CXCL10), …
References (Sources)
- .01 Pattern recognition receptors: immune targets to enhance cancer immunotherapy
- Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies
- Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells
- Molecular and Structural Basis of DNA Sensors in Antiviral Innate Immunity
- Protective role for Toll-like receptor-9 in the development of atherosclerosis in apolipoprotein E-deficient mice
- TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7–9