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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Amyloid-beta (Aß, Abeta) / Amyloid Plaques & Astrocyte activation

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MAPK pathways mediate beta-amyloid induced astrocyte activation, which is the crucial hallmark in the pathogenetic process of AD
Saha et al. 2020 Mol. Cell. Neurosci. 108: 103551 (IM)

JNK and p38K, but not ERK pathways, are activated in Amyloid-beta (Aß, Abeta) / Amyloid Plaques-treated astrocytes in culture and the beta-amyloid-infused rat brain cortex.
Sah…

Astrocytes and oligodendrocytes undergo subtype-speciﬁc transcriptional changes in Alzheimer’s disease
Sadick et al. 2022 Neuron 110: 1788-1805
Disease-associated astrocytes in Alzheimer’s disease and aging
Habibet al. 2020 Nat Neurosci 23: 701-706
P38K and JNK pathways are induced by amyloid- β in astrocyte: Implication of MAPK pathways in astrogliosis in Alzheimer’s disease
Saha et al. 2020 Mol. Cell. Neurosci. 108: 103551

5/29/2026