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By the interaction of peptidoglycan with NOD2 are the kinase receptor-interacting protein 2 (RIP2 also known as RIPK2) and nuclear factor-κB (NFKB) activated. Result of the signaling cascade is the induction of the production of antimicrobial peptides (AMPs) and mucin
Muramyl dipeptide, a peptidoglycan motif in both gram-positive and -negative bacteria, is the natural ligand of NOD2
Correa et al. 2012 Bios…