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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Siderophores

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Siderophores, iron-scavenging small molecules (iron chelators), are fundamental to bacterial nutrient metal acquisition facilitating cellular iron transport. They are bacterial iron acquisition mechanisms
Raymond et al. 2003 Proc. Natl. Acad. Sci. USA 100: 3584-3588
Perry et al. 2019 Proc Natl Acad Sci USA 116: 21980–21982
Hoffmann et al. 2025 Trends in Pharmacological Sciences 46(10): 1004-1017

Siderophores are synthesized and secreted by certain Commensal Bacteria / Commensalism and pathogens, and act to retrieve [iron](brain://98BsD3i39EmP…

References (Sources)

Bacterial siderophores in community and host interactions
Kramer et al. 2020 Nat Rev Microbiol 18: 152-63
Review
Enterobactin: an archetype for microbial iron transport
Raymond et al. 2003 Proc. Natl. Acad. Sci. USA 100: 3584-3588
Staphylococcus aureus exhibits heterogeneous siderophore production within the vertebrate host.
Perry et al. 2019 Proc Natl Acad Sci USA 116: 21980–21982
Tackling microbial iron homeostasis: novel antimicrobial strategies
Hoffmann et al. 2025 Trends in Pharmacological Sciences 46(10): 1004-1017
Review
The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens
Kim et al. 2017 Immunol Rev. 279(1): 90-105

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Siderophores

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