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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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CD4+ Th2 cells & Inflammation / Inflammatory diseases

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CD4+ Th2 cells, particularly Pathogenic Th2 (Tpath2) cells, are implicated in various inflammatory diseases: Allergic airway inflammation, tissue repair and fibrosis.

Tpath2 cells are key drivers of allergic airway inflammation
Nakayama et al. 2021 Int Immunol. 33(12): 699-704

They contribute to conditions such as asthma, chronic rhinosinusitis with nasal polyps, and allergic rhinitis
Cheon et al. 2024 Int J Mol Sci. 25(17): 9455

Conventional CD4+ Th2 cells contribute to tissue repair after inflammatory reactions. Their uncontrolled act…

References (Sources)

CD4+ T cells in inflammatory diseases: pathogenic T-helper cells and the CD69-Myl9 system
Nakayama et al. 2021 Int Immunol. 33(12): 699-704
Review
Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis
Kokubo et al. 2022 Front Immunol. 13: 945063
Review
Critical Role of TSLP Receptor on CD4 T Cells for Exacerbation of Skin Inflammation
Kitajima et al. 2020 J Immunol. 205(1):27-35
Extrathymically generated Treg cells control mucosal Th2 inflammation.
Josefowicz et al. 2012
Functions and Clinical Applications of Extracellular Vesicles in TH2 Cell-Mediated Airway Inflammatory Diseases: A Review
Cheon et al. 2024 Int J Mol Sci. 25(17): 9455
Review
Th1/Th2 cells
Romagnani 1999 Inflamm Bowel Dis. 5(4): 285-94
The Regulation of Intestinal Inflammation and Cancer Development by Type 2 Immune Responses
Gamez-Belmonte et al. 2020 Int. J. Mol. Sci. 21: 9772
Review

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CD4+ Th2 cells & Inflammation / Inflammatory diseases

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