CD4+ Th2 cells & Inflammation / Inflammatory diseases

CD4+ Th2 cells, particularly Pathogenic Th2 (Tpath2) cells, are implicated in various inflammatory diseases: Allergic airway inflammation, tissue repair and fibrosis.

Tpath2 cells are key drivers of allergic airway inflammation
Nakayama et al. 2021 Int Immunol. 33(12): 699-704

They contribute to conditions such as asthma, chronic rhinosinusitis with nasal polyps, and allergic rhinitis
Cheon et al. 2024 Int J Mol Sci. 25(17): 9455

Conventional CD4+ Th2 cells contribute to tissue repair after inflammatory reactions. Their uncontrolled activation can lead to pathological fibrosis and organ failure
Kokubo et al. 2022 Front Immunol. 13: 945063

see also:
Pathogenic Th2 (Tpath2) cells