Immune phenotypic markers (CD markers): CD45+, CD19+, CD2ß+, CD24+, CD38, CD22
Location: Blood, Lymphoid tissues
Following antigen-dependent activation of the B cell receptor and supportive signals from CD4+ T cells, B cells differentiate into cells capable of BCR diversification, antibody secretion, or long-term memory
B cells can act as antigen presenting cells
B cells are one of the dominant cell types expressing MHC class II molecules
B cells present processed antigens via MHC II to CD4+ Th2 cells
B cells recognize Alarmins / Damage-associated molecular pattern (DAMPs), too
B cells are required to generate optimal antitumor immunity in response to PD-1 blockade
see also:
Plasmablast / Plasma cells