Immature DC (iDC) / Langerhans Cells

Immature dendritic cells (iDCs), also known as Langerhans cells (LCs), are a specialized subset of antigen-presenting cells (APCs) that play a crucial role in the immune surveillance of the epidermis, the outermost layer of the skin. These cells are strategically positioned to act as immune sentinels, capturing antigens at the skin barrier and migrating to lymph nodes to prime T- and B-lymphocytes, leading to a variety of immune responses
Neagu et al. 2022 J Pers Med. 12(12): 2072

Langerhans cells have been shown to be capable of inducing the proliferation of skin-resident CD8 memory T cells, which are …