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Interleukin-12 (IL-12)
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Contents
Interleukin-12 (IL-12) is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
Interleukin-12 (IL-12) is a pro-inflammatory cytokine and a crucial factor for Th1 polarization
Interleukin-12 (IL-12) is produced in:
- Monocytes
- Macrophages (CD68s)
- Neutrophils / Neutrophilic Granulocytes
- [Microglia](brain://pVIbm-61VUKPhT…
References (Sources)
- Innate and adaptive effects of inflammasomes on T cell response
- Interleukin-12 and the regulation of innate resistance and adaptive immunityReview
- Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: receptors, functions, and roles in diseases
- Production of complement components by cells of the immune system
- Progressive loss of RORγt expression confers distinct functional fates to natural killer cell receptor-expressing RORγt+ innate lymphocytes
- The functional significance of epitope spreading and its regulation by co-stimulatory molecules
- The immunomodulatory effect of plant lectins: a review with emphasis on ArtinM propertiesReview