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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Deoxycholic Acid (DCA)

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Deoxycholic acid (DCA) feeding induced fibrotic changes
Holtmann et al. 2021 Cell 10: 2618

A set of six enzymes is necessary and sufficient for the eight-step conversion of cholic acid to Deoxycholic Acid (DCA)
Funabashi et al. 2020 Nature 582: 566

Deoxycholic Acid (DCA) & 5-HT release

Deoxycholic Acid (DCA) induces the release of 5-HT by binding to TGR5 in Enteroendocrine Cells (EEC)
Kayama & Takeda 2020

References (Sources)

A metabolic pathway for bile acid dehydroxylation by the gut microbiome
Funabashi et al. 2020 Nature 582: 566
Bile Acids Activate NLRP3 Inflammasome, Promoting Murine Liver Inflammation or Fibrosis in a Cell Type-Specific Manner
Holtmann et al. 2021 Cell 10: 2618
Dysbiosis-Induced Secondary Bile Acid Deﬁciency Promotes Intestinal Inﬂammation
Sinha et al. 2020 Cell Host & Microbe 27: 659-670
Manipulation of epithelial integrity and mucosal immunity by host and microbiota-derived metabolites
Kayama & Takeda 2020

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5/29/2026

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Deoxycholic acid - Wikipedia