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Accumulation of beta-amyloid is a common pathology in AD.
Beta-amyloid (Aß) is a peptide derived from the proteolytic cleavage of an APP.
Fibril-structured amyloid-beta (Aβ) oligomers have potent antimicrobial properties.
These can trap pathogens and destroy their membranes.
Amyloid beta may play a protective role in the innate immune response to microbial infections .
Recently, Aβ has also been recognized as an antimicrobial peptide participating in the innate immune response
Beta-amyloid production is in turn prevented by alfa-secretase activity, which cleaves amyloid precursor protein (APP) within the beta-amyloid domain
Rosenberg et al. 2018 Alzheimers Res Ther. 10: 115
Aβ oligomers are also internalized by microglia. This process involves Scavanger receptor AI (SR-AI), Integrin alfa-6-beta-1, CD36 (Platelet glycoprotein IV or IIIb (GP IV / GP IIIb), and CD47 (integrin associated protein (IAP)).
Beta-amyloid -deposits may occur at different axis levels, including both the central and enteric nervous systems