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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Hypoxia-inducible factor 1 alfa (HIF1A, HIF-1 alfa)

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HIF-alfa factors are potential therapeutic targets in leukemia .
Magliulo & Bernardi 2018 Expert Opin.Ther.Targ. 22: 917-928

Hypoxia-inducible factor 1 alfa (HIF1A, HIF‑1 alfa) is a key transcriptional regulator of glycolytic rate in innate immune cells, including macrophages
Palsson‑McDermott et al. 2015 Cell Metab 21: 65‑80

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References (Sources)

HIF-α factors as potential therapeutic targets in leukemia
Magliulo & Bernardi 2018 Expert Opin.Ther.Targ. 22: 917-928
Review
Pyruvate kinase M2 regulates Hif‑1 α activity and IL‑1β induction and is a critical determinant of the Warburg effect in LPS‑activated macrophages
Palsson-McDermott et al. 2015 Cell Metab 21: 65-80

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12/16/2025

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Hypoxia-inducible factor 1 alfa (HIF1A, HIF-1 alfa)

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