meRfi®-GM
Lipopolysaccharides (LPS)
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Contents
Lipopolysaccharide (LPS) is a crucial component of Gram-negative bacteria that plays a role in innate immunity. It activates the Toll-like receptor (TLR)-4 receptor on cell membranes and the cytosolic receptor caspase-11, leading to inflammasome activation and pyroptosis. The mechanism by which LPS enters host cells involves bacterial outer membrane vesicles (OMVs), the spike protein of SARS-CoV-2, host-secreted proteins, and host [extracellular vesicles …
References (Sources)
- Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS)
- Connection between gut microbiome and the development of obesity
- Gut Microbiome Dysbiosis and Immunometabolism: New Frontiers for Treatment of Metabolic DiseasesReview
- Gut Microbiota-Derived Short-Chain Fatty Acids Facilitate Microbiota:Host Cross talk and Modulate Obesity and Hypertension
- Lipopolysaccharide from gut microbiota modulates alpha-synuclein aggregation and alters its biological function
- The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome
- Total lipopolysaccharide from the human gut microbiome silences toll-like receptor signaling.