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The vast majority of available sugars in the large intestine are diet and host-derived complex carbohydrates which are indigestible by the host.
A high-sugar diet unbalances the microbiome, so the body makes fewer of the gut immune cells that help to prevent metabolic disorders
The vagus nerve responds to sugars and sweeteners
The vagal response to sugars, sugar analogs and non-caloric [sweeteners](brain://pT4KXXfrvU2xf6M4x…