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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Bile salts / Bile acids & Clostridioides (Clostridium) difficile

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Primary bile acids (PBAs) promote Clostridioides (Clostridium) difficile spore germination in vitro, whereas certain Secondary bile salts / Secondary bile acids (SBAs) inhibit its vegetative growth.
Sorg & Sonenshein 2009 J Bacteriol 191: 1115-7
Weingarden et al. 2016 PLoS One 11: e0147210

Deoxycholic acid (DCA) and lithocholic acid (LCA) block the growth of [Clostridium difficile](brain://S1Y4QnhYKEC6XibNxuhXIQ/Clostr…

Bile salts and glycine as cogerminants for Clostridium difficile spores
Sorg & Sonenshein 2008 J. Bacteriol. 190: 2505–2512
Changes in colonic bile acid composition following fecal microbiota transplantation are sufficient to control clostridium difficile germination and growth
Weingarden et al. 2016 PLoS One 11: e0147210
Chenodeoxycholate is an inhibitor of Clostridium difficile spore germination
Sorg & Sonenshein 2009 J Bacteriol 191: 1115-7
Contribution of Inhibitory Metabolites and Competition for Nutrients to Colonization Resistance against Clostridioides difficile by Commensal Clostridium
Reed & Theriot 2021
Review
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
Yoshimoto et al. 2013 Nature. 499: 97-101
Role of the Intestinal Microbiota in Resistance to Colonization by Clostridium difficile
Britton & Young 2014
Review
The bile acid TGR5 membrane receptor: from basic research to clinical application
Duboc et al. 2014 Dig. Liver Dis. 46: 302–312
Review

5/29/2026