Cholesterol & Microglia

Microglia, along with astrocytes, are involved in cholesterol metabolism and transport within the Central Nervous System (CNS). Apolipoprotein E (APOE) is a key player in cholesterol transport and metabolism in the brain.

Apolipoprotein E (APOE) 4 (APOE4) is associated with cholesterol dysregulation in microglia, leading to lipid accumulation and altered inflammatory responses. This dysregulation can contribute to neurodegenerative processes, particularly in the context of tauopathies and Alzheimer's disease
Litvinchuk 2023 Alzheimer's & Dementia 19:

see also:
Alzheimer's Disease (AD) & Microglia
Alzheimer's Disease (AD) & Tau Protein
Microglia