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Pyrin domain (PYD / PAAD / DAPIN) is present at the N-terminus of a protein. Proteins that have a pyrin domain engage with the pyrin domains found in other proteins. This interaction leads to the formation of multi-protein complexes known as inflammasomes, which subsequently initiate downstream immune responses.
Pyrin Domain (PYD) of NLRP3 interacts with the PYD domain of Adaptor Protein (apoptosis-associated speck-like protein) (ASC)
Moreover, Pyrin domain (PYD / PAAD / DAPIN) interacts with the PYD domains of …