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Adaptor Protein (apoptosis-associated speck-like protein) (ASC)
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Contents
Adaptor Protein (apoptosis-associated speck-like protein) (ASC) as an adaptor protein contains two domains: the Pyrin domain (PYD / PAAD / DAPIN) at the N-terminus and a CARD at the C-terminus. It is part of apoptosis. NFKB is activated, and the CARD recruits pro-caspase-1, which undergoes proximity-induced autocleavage to form the active caspase-1, which…
References (Sources)
- Emerging inflammasome effector mechanismReview
- Fire and ICE: the role of pyrin domain-containing proteins in inflammation and apoptosis
- Identification of multifaceted binding modes for pyrin and ASC pyrin domains gives insights into pyrin inflammasome assembly
- Innate Immunity
- The PYRIN domain in signal transduction
- The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation