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Pyrin domain (PYD / PAAD / DAPIN)
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Contents
Pyrin domain (PYD / PAAD / DAPIN) is present at the N-terminus of a protein. Proteins that have a pyrin domain engage with the pyrin domains found in other proteins. This interaction leads to the formation of multi-protein complexes known as inflammasomes, which subsequently initiate downstream immune responses.
Pyrin Domain (PYD) of NLRP3 interacts with the PYD domain of Adaptor Protein (apoptosis-associated speck-like protein) (ASC)
Moreover, Pyrin domain (PYD / PAAD / DAPIN) interacts with the PYD domains of …
References (Sources)
- An updated view on the structure and function of PYRIN domains
- Fire and ICE: the role of pyrin domain-containing proteins in inflammation and apoptosis
- Identification of multifaceted binding modes for pyrin and ASC pyrin domains gives insights into pyrin inflammasome assembly
- Innate and adaptive effects of inflammasomes on T cell response
- Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developrnents
- The PYRIN domain in signal transduction