Caspase Recruitment Domains (CARDs)

NOD-like receptors (NLRs) come together to form oligomers and connect with adaptor proteins that contain a caspase-recruitment domain (CARD). This domain is a short module responsible for protein-protein interactions, which facilitates the recruitment of Inflammatory Caspases (group I caspases).
Srinivasula et al. 2002 J Biol Chem 277: 21119-21122

In the process of recruitment and activation, caspases remove the C-terminal repressor domain from gasdermins. This action releases the free N terminus, which then creates large pores in the cell membrane.
Kayagaki et al. 2015 Nature 526: 666-671
Shi et al. 2015 Nature 526: 660-665
Ding et al. 2016 Nature 535: 111-116
Liu et al. 2016 Nature 535: 153-158
Sborgi et al 2016 EMBO J 35: 1766-1778

see also:
Gasdermins & Family Members
Gasdermin D (GSDMD)
Caspase-11 (mice) & Pyroptosis
NLRP3 Inflammasome
Pyroptosis