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Interleukin-1 (IL-1) beta (IL-1F2) is primarily produced by phagocytes in response to MAMPs that induce transcription of IL-1beta mRNA, whereas inflammasomes promote proteolytic activation of IL-1beta and assembly of gasdermin pores, facilitating non-canonical secretion of the active cytokine and induction of pyroptosis
IL-1 is required for tumor invasiveness and angiogenesis.
Interleukin-1 (IL-1) beta (IL-1F2) activates PI3K-MDM2 and negatively regulates the p53 pathway, thus increasing the survival of DNA-damaged cells, which may lead to the development of HCC
Interleukin-1 (IL-1) beta (IL-1F2) induces differentiation of Th17 cells secreting IL-17 alongside with IFN-gamma
Interleukin-1 (IL-1) beta (IL-1F2) has suppressive effects on Treg and IL-10 production
Interleukin-1 (IL-1) beta (IL-1F2) has been shown to play a vital role in Contact hypersensitivity
Interleukin-1 (IL-1) beta (IL-1F2) is constitutively produced by MDC and monocytes
IL-1beta is the first non-T cell-derived cytokine identified that enhances CD40L-mediated activation of DC