AvrA

AvrA is a product of Salmonella that influences the pathways of eukaryotic cells during infection (1). AvrA can activate epithelial beta-catenin signaling (2). AvrA persistently regulated beta-catenin posttranslational modifications, including phosphorylation and acetylation (2). AvrA is a Salmonella type-three secretion effector that is multifunctional, inhibiting intestinal inflammation and enhancing proliferation (2). AvrA has a chronic function in promoting intestinal proliferation (2).

References:

(1) Lu et al. 2014 Oncogenesis. 3: e105
(2) Lu et al. 2012 Am. J. Physiol. Gastrointest. Liver Physiol. 303: G1113–G1125