Loading…
Please register to continue your trial period!
meRfi-GM provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.
Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.
Start your free trial and transform your understanding of the gut microbiota today!
Tryptophan metabolites from the Kynurenine Pathway by the gut microbiota suppress inflammatory responses in the macrophages.
Kynurenines serve as precursors for signaling molecules and are the first step in de novo NAD+ synthesis. In mammalian cells, the kynurenine pathway is initiated by the rate-limiting enzymes tryptophan-2,3-dioxygenase (TDO) and interferon-responsive Indoleamine 2,3-Dioxygenase (IDO). This pathway…