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Beta-glucuronidases & Irinotecan
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Contents
Microbial beta-glucuronidases in the gut can reactivate the excreted, inactive metabolite of irinotecan. Reactivation results in adverse drug reactions, including severe diarrhea. Inhibition of these enzymes may reduce irinotecan-related adverse reactions in select patient populations.
see also:
Beta-glucuronidases
Beta-glucuronidases & Xenobiotics biodegradation / Drug metabolism
[Gut microbiota & Irinotecan](brain://YMkGWwr1i0Si5HYieZdNVA/GutMicrobiotaIrino…