meRfi®-GM
Peptidoglycans & Pattern Recognition Receptors (PRRs)
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The target structures for the bacterial peptidoglycan components such as muramyl dipeptide (MDP) and gamma-glutamyl diaminopimelic acid (iE-DAP) are the intracellular cytosolic Pattern Recognition Receptors (PRRs) NOD1 and NOD2. The prerequisite for this interaction is the S-palmitoylation of NOD1 and NOD2 by the [ZDHHC5](…