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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

NLRP6 (NOD-like receptor family pyrin domain containing 6)

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Functionally,NLRP6 (NOD-like receptor family pyrin domain containing 6) is thought to bind ASC, which subsequently engages caspase-1 or caspase-11, and matures gasdermin D and interleukin (IL)-18 as an inﬂammasome. The NLRP6 inflammasome identifies lipoteichoic acid and controls infections caused by Gram-positive [pathogens](brain://aKAC0T2fKU6Ss8xccK…

A functional role for Nlrp6 in intestinal inflammation and tumorigenesis
Chen et al. 2011 Journal of immunology 186: 7187-7194
Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.
Levy et al. 2015 CELL 163: 1428-1443
Molecular mechanism for NLRP6 inﬂammasome assembly and activation
Shen et al. 2019 Proc Natl Acad Sci USA 116: 2052-2057
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
Elinav et al. 2011 Cell 145: 745-757
The NLRP6 Inﬂammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection
Hara et al. 2018 Cell 175: 1651-1664

4/13/2026