meRfi®-GM
NLRP6 (NOD-like receptor family pyrin domain containing 6)
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Contents
Functionally,NLRP6 (NOD-like receptor family pyrin domain containing 6) is thought to bind ASC, which subsequently engages caspase-1 or caspase-11, and matures gasdermin D and interleukin (IL)-18 as an inflammasome. The NLRP6 inflammasome identifies lipoteichoic acid and controls infections caused by Gram-positive [pathogens](brain://aKAC0T2fKU6Ss8xccK…
References (Sources)
- A functional role for Nlrp6 in intestinal inflammation and tumorigenesis
- Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.
- Molecular mechanism for NLRP6 inflammasome assembly and activation
- NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
- The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection