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Oxysterols interact with the liver X receptor (LXR), which is considered to be particularly important concerning inflammatory processes and metabolic diseases (hyperlipidemia, atherosclerosis)
Oxysterols are becoming pivotal bioactive lipids which have been underestimated for a long time. Their actions are ranging from regulation of energy homeostasis (i.e., glucose and lipid metabolism) to inflammation and immunity, thereby opening the avenue to new treatments to tackle metabolic disorders associated with obesity (e.g., type 2 diabetes and hepatic steatosis) and inflammatory diseases.
Oxysterols form the starting materials for the synthesis of primary bile acids in hepatocytes with the involvement of various enzymes.
Oxysterols sensing through the receptor GPR183 promotes the lymphoid-tissue-inducing function of innate lymphoid cells and colonic inflammation.
see also:
Colitis / Intestinal Inflammation & Interleukin-10 (IL-10)