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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Butyrate / Butyric acid & Dendritic cells (DCs)

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Dendritic Cells (DCs) exposed to Butyrate / Butyric acid express aldehyde dehydrogenase 1 family member A2 (ALDH1A2)
Gurav et al. 2015 Biochem J. 469(2): 267-278

Dendritic Cells (DCs) exposed to Butyrate / Butyric acid suppress conversion of naïve T cells into pro-inflammatory IFN-gamma-producing cells
Gurav et al. 2015 Biochem J. 469(2): 267-278

Treatment of macrophages with Butyrate / Butyric acid led to the downregulation o…

References (Sources)

Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases
Singh et al. 2010 Journal of Biological Chemistry. 285:27601-27608
Butyrate affects differentiation, maturation and function of human monocyte-derived dendritic cells and macrophages
Millard et al. 2002 Clin Exp Immunol. 130: 245-255
Slc5a8, a Na+-coupled high-afﬁnity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and CRC under low-ﬁbre dietary conditions
Gurav et al. 2015 Biochem J. 469(2): 267-278
The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition
Chang et al. 2014 Proc. Natl. Acad. Sci. U. S. A. 111: 2247–2252

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Butyrate / Butyric acid & Dendritic cells (DCs)

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