meRfi®-GM
Primary bile acids (PBAs)
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Contents
Only about 5% of primary bile acids escape into the large intestine, where they are modified by gut microbiota into Secondary bile salts / Secondary bile acids (SBAs), such as the highly toxic deoxycholic acid (DCA), lithocholic acid (LCA), and ursodeoxycholic acid (UDCA) through a multistep process that involves deconjugation and dehydroxylation. This modification is facilitated by bacterial [bile salt hydrolases]…
References (Sources)
- Bile Acid signaling in liver metabolism and diseases
- Bile Acids, Liver Cirrhosis, and Extrahepatic Vascular Dysfunction
- Bile acids: trying to understand their chemistry and biology with the hope of helping patients
- Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation
- Environmental Chemical Contribution to the Modulation of Bile Acid Homeostasis and Farnesoid X Receptor Signaling
- Interactions between bile salts, gut microbiota, and hepatic innate immunity
- Role of Bile Acids in the Regulation of Food Intake, and Their Dysregulation in Metabolic DiseaseReview