G-Protein Coupled Receptor 43 (GPR43) & Neutrophils / Neutrophilic Granulocytes

In neutrophils, G-Protein Coupled Receptor 43 (GPR43) activation triggers chemotaxis. It may promote survival or apoptosis. It enhances superoxide production. This involves crosstalk with P2Y purinoceptor 2 (P2RY2). It also boosts Interleukin-1 (IL-1) beta (IL-1F2) cytokine production. In Group 3 ILCs (ILC3), G-Protein Coupled Receptor 43 (GPR43) activation by acetate upregulates Interleukin-1 (IL-1) receptors (IL-1R). IL-1R is activated by IL-1b. This leads to an increased IL-22 production. FFA2 activation also directly produces IL-22. This occurs via the Akt/ERK1/2-STAT3-RORγt axis and promotes ILC3 expansion
Alexander & Turnbaugh 2020
Bolognini et al. 2021

They (propionate > butyrate > acetate) induce neutrophils by activating the GPR43 to migrate to foci of inflammation (chemotaxis)
Sina et al. 2009 J Immunol. 183(11): 7514–22.

There, they exert their phagocytic property
Vinolo et al., 2009 Clin Sci (Lond). 117(9): 331–8
Vinolo et al., 2009a Cell Biochem Funct. 27(1):48–55

see also:
Inflammation / Inflammatory Diseases & Neutrophils / Neutrophilic Granulocytes
Interleukin-22 (IL-22) & Signal transducer and activator of transcription 3 (STAT3)
Neutrophils / Neutrophilic Granulocytes & Short-Chain Fatty Acids (SCFAs)