Toll-like receptor 3 (TLR-3)

Toll-Like Receptor 3 (TLR-3) is endosomal localized

Toll-Like Receptor 3 (TLR-3) is unique among Toll-Like Receptors (TLRs) as it does not activate via the MyD88 / NFKB / MAPK Signal transduction Pathway. Instead, it activates NFKB and Interferon (IFN) Regulatory Factor 3 (IRF3) through the TRIF-Dependent Pathway
Yang et al. 2020j

Toll-Like Receptor 3 (TLR-3) engagement increases production of Interferons Type I (IFN Type I), Interferon type III (IFN Type III), Chemokine (C-X-C motif) ligand 9 (CXCL9), and Chemokine (C-X-C motif) ligand 10 (CXCL10), all of which are cytokines that favor T cell recruitment and activation
Zanoni et al. 2011 Cell 147: 868-880
Patel & Minn 2018 Immunity 48: 417

It is found in:

• Conventional (or classical) dendritic cells (cDCs)


• Natural killer cells (NK cells)

Holtick et al., 2011
Shekarian et al. 2017 Ann Oncol. 28(8): 1756-1766

The ligands of Toll-Like Receptor 3 (TLR-3) are
dsRNA (viruses), Polyinosinic-polycytidylic acid (poly-ICLC)

Toll-Like Receptor 3 (TLR-3) exclusively uses TIR domain containing adaptor molecule 1 (TICAM1) for signaling
West et al. 2006 Annu Rev Cell Dev Biol. 22: 409-37

see also:
PAMPs (pathogen-associated molecular patterns) & Toll-Like Receptors (TLRs)
Toll-Like Receptor 3 (TLR-3) agonists