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4-Aminobutyric acid / GABA deficiency in C. elegans increases susceptibility to pathogenic Pseudomonas aeruginosa PA14 infection
4-Aminobutyric acid / GABA acts as a neurotransmitter between enteric neurons and intestinal smooth muscle. By that, the neuropeptide FLP-6 is expressed and secreted by smooth intestinal muscle cells
FMRFamide-like neuropeptide FLP-6 repressed the transcription factors ZIP-10 and Krüppel-like factor 1 (KLF1), which acted in parallel and converged on PMK-1/p38 signaling in the gut epithelium to ensure innate immunity and gut defenses
4-Aminobutyric acid / GABA is the main inhibitory neurotransmitter in the mammalian CNS. As cultivation experiments have shown, some bacteria appear to require GABA to thrive. Others produce GABA; more than 30 are already known. These have significant psychobiotic potential since they can increase GABA levels in the brain
4-Aminobutyric acid / GABA producing bacterial species and strains among three groups of bacteria, including Bacteroides.
There is a bacterium that couldn’t survive on typical culture media and required an amino acid called gamma-aminobutyric acid (GABA) to thrive
If this gut microbe had to have 4-Aminobutyric acid / GABA , some other microbe must be making it. Such 4-Aminobutyric acid / GABA-producing bacteria might be a psychobiotic gold mine
Bacteria produce GABA in the rat digestive tract, which can increase 4-Aminobutyric acid / GABA levels in the brain
4-Aminobutyric acid / GABA , the major CNS inhibitory neurotransmitter, is also produced by the families Bifidobacterium , Lacticaseibacillus (Lactobacillus) , and Streptococcus
see also:
4-Aminobutyric acid / GABA-producing bacteria
Gut microbiota & Hormones / Hormone System