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The microbiota present in the mesenteric adipose tissue of individuals with Crohn's disease can induce colitis in mice. The key pathogens Achromobacter pulmonis and Klebsiella variicola are responsible for the exacerbation of colitis. The mesenteric adipose tissue-derived bacterium, Klebsiella variicola, disrupts the intestinal barrier and promotes colitis through the Type VI secretion system.
During Intestinal Inflammation and Associated Bleeding, There Is a Massive Loss of Iron
Aberrant host-microbiota interactions underlie intestinal inflammation
Th1 and Th17 cells, as well as IL-23-dependent innate lymphoid cells, promote colitis in models in which Treg cells are depleted
The inflammation in the gut is linked to systemic inflammation and may play a role in triggering the development of certain autoimmune diseases, as well as contributing to their severity
Sartor 1997 Aliment Pharmacol Ther 11 (Suppl_3): 17-22
see also:
Creeping Fat (CrF) & Crohn's disease (CD)
Experimental Colitis