Genotoxins / Genotoxicity

Among the most well-described genotoxic bacteria are enterotoxigenic Bacteroides fragilis (ETBF) (Wu et al. 2009 Nat. Med. 15: 1016) that produce Bacteroides fragilis toxin (BFT), strains of Escherichia coli or other bacteria that produce colibactin (Nougayrède et al., 2006 Science 313: 848-851), and Campylobacter jejuni strains that express Cytolethal distending toxin (CDT) (Lara-Tejero & Galán 2000 Science 290: 354)

Unexpected members of the gut microbiota produce diverse host cell genotoxins. One example is Aspartate aminotransferase (aat)–positive Morganella morganii producing newly identified genotoxic metabolites. These indolimines may generate double-stranded DNA breaks that could lead to mutagenesis. The production of indolimines is required to promote colonic tumorigenesis when these bacteria are transplanted into a susceptible mouse model (see also: Colorectal Cancer (CRC) & Genotoxins / Genotoxicity)
Puschhof & Sears 2022 Science 378(6618): 358-359

see also:
Cytolethal distending toxin (CDT)