Cancer / Tumors & Polyamines / Polyamine

Excessive release of polyamines in the tumor microenvironment directs Treg cells towards immunosuppression in a protein kinase CK2 -dependent manner. Polyamine deprivation or inhibition of Protein Kinase CK2 activity in Treg cells induces tissue reparative properties.
Bündgen et al. 2025 Immunity 58: 2019-2034

Aberrant polyamine metabolism with high polyamine concentrations is linked to cancer development
Miller-Fleming et al. 2015 J. Mol. Biol. 427: 3389-3406
Sánchez-Alcoholado et al. 2020

In tumors, polyamines can promote cell transformation and proliferation
Proietti et al. 2020 Trends in immunology 41: 1037

Enterotoxigenic Bacteroides fragilis upregulated polyamine catabolism (aberrant polyamine metabolism), thereby exaggerating inflammation and tumorigenesis via ROS-related DNA damage
Goodwin et al. 2011

Polyamines are known to be strong activators of protein kinase CK2.
Cochet & Chambaz 1983 Mol Cell Endocrinol 30: 247-266

see also:
Biosynthesis & Polyamines / Polyamine
Colitis / Intestinal Inflammation & Enterotoxigenic Bacteroides fragilis (ETBF)
Colorectal Cancer (CRC) & Enterotoxigenic Bacteroides fragilis (ETBF)
Colorectal Cancer (CRC) & Polyamines / Polyamine
Enterotoxigenic Bacteroides fragilis (ETBF) & Inflammatory Bowel Disease (IBD)
Enterotoxigenic Bacteroides fragilis (ETBF) & Polyamines / Polyamine