meRfi®-GM
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Cancer / Tumors & Polyamines / Polyamine
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Contents
Excessive release of polyamines in the tumor microenvironment directs Treg cells towards immunosuppression in a protein kinase CK2 -dependent manner. Polyamine deprivation or inhibition of Protein Kinase CK2 activity in Treg cells induces tissue reparative properties.
Aberrant polyamine metabolism with high polyamine concentrations is linked to cancer development
Sánchez-Al…
References (Sources)
- Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis induced colon tumorigenesis
- Polyamine-mediated protein phosphorylations: A possible target for intracellular polyamine action
- Polyamines and Kynurenines at the Intersection of Immune Modulation
- Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells
- Remaining Mysteries of Molecular Biology: The Role of Polyamines in the Cell
- The Role of the Gut Microbiome in Colorectal Cancer Development and Therapy Response