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Biological effects / Functions & Butyrate / Butyric acid
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Butyrate has dual roles in normal and tumor colonocytes. In normal cells, it serves as an energy source, metabolized to acetyl-CoA in the Krebs cycle, promoting cell proliferation. In tumor cells, due to the Warburg effect, butyrate does not enter the Krebs cycle but instead modulates gene expression through HDAC inhibition, leading to downregulatio…
References (Sources)
- Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases
- Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases
- Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella
- Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes
- Gut microbiota as an“invisible organ”that modulates the function of drugsReview
- Role of short-chain fatty acids in colonic inflammation, carcinogenesis, and mucosal protection and healing
- Short chain fatty acids in human large intestine, portal, hepatic and venous blood